• The pseudo DUBs KIAA and Abraxas are required for the

  2019-07-31

  

  The pseudo DUBs KIAA0157 and Abraxas are required for the catalytic function of BRCC36. Comparison of the BRCC36–KIAA0157 heterodimer structure with an inactive BRCC36 homodimer structure provides a model for understanding how this functional interplay is achieved. As shown in schematic form in Figu

• br Materials and methods br Results br Discussion

  2019-07-31

  

  Materials and methods Results Discussion Plg plays important roles in various physiological processes, such as fibrinolysis, proteolysis, cell migration, differentiation, tissue remodeling, and inflammation [6], [7], [8]. We herein found that Plg deficiency enhanced insulin secretion, and w

• Apart from its high affinity

  2019-07-30

  

  Apart from its high affinity, the selection of GW2580 as 11-dUTP lead in our radiotracer development program was motivated by its exceptional selectivity. The observed profound impact of small structural modifications on the selected panel of four kinases tested prompted us to conduct comprehensive

• br Conclusion In this study we investigated

  2019-07-30

  

  Conclusion In this study, we investigated functional alterations of ECs following exposure to mechanical and/or physicochemical stimuli. Specifically, hypoxia induced phosphorylation with significant increases after 30 min and the maximum increase was after 180 min. Our data show that a combinati

• Studies have shown that endothelial cells damaged by

  2019-07-30

  

  Studies have shown that endothelial cells damaged by SAH can release a large amount of ET-1, thus its plasma level is elevated and is positively correlated with the symptoms of SAH (Lei et al., 2015, Masaoka et al., 1989). Our data obtained from SAH-along rabbits were consistent with these findings.

• The effect of ET activity on the development of

  2019-07-30

  

  The effect of ET-1 activity on the development of experimental pulmonary fibrosis has also been examined by other investigators. One study found that repeated administration of Bosentan, an ERA used to treat pulmonary arterial hypertension (PAH), significantly decreased bleomycin-induced pulmonary f

• Introduction Excessive exposure to ultraviolet

  2019-07-30

  

  Introduction Excessive exposure to ultraviolet (UV) irradiation from the sun injures human skin, which might lead to premature aging and skin pathologies [1], [2]. Chronic exposure to UV (especially ultraviolet-B, UVB) irradiation could profoundly affect the skin epidermis, interfering with the ker

• Consistent with the known tolerance of the Suzuki Miyaura

  2019-07-30

  

  Consistent with the known tolerance of the Suzuki–Miyaura reaction to a wide range of aryl substituents, we subsequently found that the commercially available 3-hydroxyphenylboronic hiv protease pinacol ester () could be coupled to , to give directly and in comparable yield. Smooth conversion of int

• In this review focusing on biocatalyst formate dehydrogenase

  2019-07-30

  

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic Tirapazamine oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation and CO

• We also identified a role for the transcription factor p

  2019-07-30

  

  We also identified a role for the transcription factor p53 in the regulation of the Crm1 promoter. p53 can activate or repress the transcription of target genes. While activation generally occurs through binding of p53 to its consensus binding site in the promoter region of target genes, for example

• br Mechanisms of acquired resistance to st and nd generation

  2019-07-29

  

  Mechanisms of acquired resistance to 1st and 2nd generation EGFR inhibitors After treatment with first or second generation EGFR TKIs, virtually all patients after approximately 12 months develop acquired resistance (AR). Different mechanisms of AR to EGFR TKIs have been reported to date and may

• Gene expression profiling with corresponding clinical data s

  2019-07-29

  

  Gene KT182 profiling with corresponding clinical data supported the notion that increased expression of S1PR1 in DLBCL was associated with poor outcome [159], [160], [161]. These studies also identified increased expression of the GPCRs GPR183, CCR7, ADRB2 and CNR2 as risk factors for poor outcome

• The first example of a broadly acting antiviral drug

  2019-07-29

  

  The first example of a broadly-acting antiviral drug is ribavirin, a nucleoside analogue that was proposed to act directly at the level of the viral polymerase, although an indirect effect via inhibition of the host-cell IMP dehydrogenase and depletion of the GTP pool seems more plausible [9]. Anoth

• Lamivudine In this context we initiated a program to

  2019-07-29

  

  In this context, we initiated a program to develop new antiviral chemotypes towards a host factor implicated in Lamivudine replication: the host (human) dihydrofolate reductase (DHFR) [21]. We recently identified this enzyme as the molecular target of 1-aryl-4,6-diamino-1,2-dihydrotriazines, struct

• Instead of introducing extra hardware or hardware modificati

  2019-07-29

  

  Instead of introducing extra hardware or hardware modification, software-based CFC techniques just insert extra checking instructions into the source code of the target program at compile time so as to have the target program do checking jobs itself. Preeminent software-based CFC techniques proposed

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