• br Steroidogenesis in the skin The synthesis

  2025-02-07

  

  Steroidogenesis in the skin The synthesis of steroid hormones takes place in many tissues of which the adrenal glands, ovaries, testis, placenta and 4-DAMP are considered to be classical steroidogenic organs. Nevertheless, skin constitutes an important peripheral steroidogenic tissue. Steroidogen

• The excellent safety profile of solanezumab and encouraging

  2025-02-07

  

  The excellent safety profile of solanezumab and encouraging trends in the exploratory analyses in mild AD led to its inclusion in two secondary prevention trials, which are continuing in the hope that earlier intervention may yield more substantial benefit. The A4 study (NCT02008357) started in Febr

• The expanding catalog of glutamate receptor auxiliary

  2025-02-07

  

  The expanding catalog of glutamate receptor auxiliary subunits and associated transmembrane proteins underscores the importance and complexity of the receptor complexes. Whereas the interactions described here specifically control AMPARs, distinct auxiliary subunits, Neto-1/2, modulate neuronal kain

• These findings suggest that eventually more than one lipoxyg

  2025-02-07

  

  These findings suggest that eventually more than one 12/15-lipoxygenase isoform may play a role in human atherosclerosis. Humans have two 12-lipoxygenases and two 15-lipoxygenases which show different expression patterns, substrate specificities and stereo-selective metabolism [1]. However, in Pyrim

• The relationship between AG and tau deposition

  2025-02-07

  

  The relationship between AG and tau deposition in the presence of Aβ burden warrants more research in AD and in other primary tauopathies (not associated with accumulation of Aβ plaques). Our findings highlight the importance of measuring AG, as this relationship was not evident for total Exemestane

• To investigate the potential link

  2025-02-06

  

  To investigate the potential link between Gβγ and MT assembly in vivo, cultured NIH3T3 and PC12 cells were used. The role of Gβγ in MT assembly was demonstrated using nocodazole, a MT depolymerizing drug [14]. We found that Gβγ was preferentially bound to MTs in NIH3T3 and PC12 cells and treatment w

• Extracellular adenosine acts as a local modulator of cell fu

  2025-02-06

  

  Extracellular adenosine acts as a local modulator of cell function via four adenosine receptor subtypes (A1Rs A2AR, A2BR, and A3R) that are involved in numerous physiological and pathophysiological processes [31]. Each is encoded by a separate gene and has different functions, although with some ove

• Regarding androgens it is known

  2025-02-06

  

  Regarding androgens, it is known that they are also essential for reproductive success (Walters et al., 2010). At the molecular level, their effects are produced mainly by dihydrotestosterone (DHT), arising from the conversion of testosterone by the enzyme 3-oxo-5-alpha-steroid-4-dehydrogenase (enco

• Epicatechin-catechin dimer It has recently been reported tha

  2025-02-06

  

  It has recently been reported that plasma and synovial fluid levels of autotaxin correlate with severity of knee OA. Synovial fibroblasts isolated from OA patients express significant amounts of autotaxin mRNA, and this increase in autotaxin Epicatechin-catechin dimer could lead to increased product

• NOXA a member of the pro apoptotic B cell

  2025-02-06

  

  NOXA, a member of the pro-apoptotic B-cell lymphoma 2 (BCL-2) family, plays a vital role in regulating mitochondrial or inherent apoptotic pathways [7,8]. NOXA binds to MCL-1 with high affinity and interacts with A1 (known as BCL2A1), resulting in BIM release to trigger subsequent apoptosis [9]. In

• On the contrary evidence also suggests that autophagy

  2025-02-06

  

  On the contrary, evidence also suggests that autophagy plays a striking protective role in cancer cells. Highly burgeoning cancer Benzazepine derivative require cellular building blocks for their metabolism and energy production. At this stage of cancer development, autophagy acts as a friend provid

• br Introduction Lung cancer is the leading cause of

  2025-02-06

  

  Introduction Lung cancer is the leading cause of cancer death worldwide and is one of the most refractory of solid tumors along with pancreatic cancer. Since 1975 there have been notable improvements in the 5-year survival rate of patients with lung cancer [1]. This improvement in survival is tho

• In the case of DIA CN the docking results

  2025-02-06

  

  In the case of DIA-4CN the docking results do not show any interaction between the iron atom and the inhibitor, presumably due to the reduced ability to form a complex involving the -CONN- moiety versus the bidentate -CONHNH- central group of HYD-4Me. This results in a considerable gap between the i

• We also show that in both ATM proficient and deficient

  2025-02-06

  

  We also show that in both ATM proficient and deficient/mutant RN486 the activation of ATR signaling is DSB complexity-dependent (Figs. 1, 4A, C and E, 6A and B). Wang et al. have also reported that the effects of ATR and CHK1 on radiosensitivity are independent of the NHEJ repair pathway [41], [42].

• The mitogen activated protein kinase

  2025-02-06

  

  The mitogen-activated protein kinase (MAPK) plays an important role in a variety of cell processes by controlling transcriptional or translational regulation [14]. There are three major MAPK family members that have been well characterized: extracellular signal-regulated kinase (ERK), c-Jun N-termin

15991 records 23/1067 page Previous Next First page 上5页 2122232425 下5页 Last page