• br Results br Discussion To further evaluate

  2022-09-06

  

  Results Discussion To further evaluate the extent of H3T3A and H3T3D roles in the segregation of sister chromatids enriched with different populations of H3 during mitosis (Figure 1B, step two), we modeled all possible segregation patterns in male GSCs and compared these estimates to our exper

• Failure of antioxidant defenses to remove exogenous ROS prod

  2022-09-06

  

  Failure of antioxidant defenses to remove exogenous ROS produced by redox cycling chemicals either by being inhibited by those compounds or overwhelmed by an excess ROS, will disrupt the balance between antioxidant/prooxidant system within the organisms leading to oxidative damage (Livingstone, 2003

• A nitric oxide donor glyceryl trinitrite

  2022-09-06

  

  A nitric oxide donor, glyceryl-trinitrite, and the substrate for nitric oxide, l-arginine, have been used to treat preterm labor. However, these studies are preliminary. The beneficial effect of nitric oxide donors needs to be confirmed by more controlled studies. The probable pitfall of using nitri

• br Introduction Human immunodeficiency virus HIV

  2022-09-06

  

  Introduction Human immunodeficiency virus-1 (HIV-1) is a retrovirus that primarily infects components of the human immune system, such as CD4+ T cells, macrophages and dendritic AZ 10606120 dihydrochloride receptor (Clapham and McKnight, 2001). HIV directly and indirectly destroys CD4+ T cells, w

• br Results br Discussion Cell contact mediated spread

  2022-09-06

  

  Results Discussion Cell-contact-mediated spread of HIV-1 has been estimated to be at least an order of magnitude more efficient compared to passive dissemination of particles through the extracellular milieu. Thus, this form of viral transmission can have significant effects on the pathogenesi

• So far GnRH receptors have been detected in the

  2022-09-05

  

  So far, GnRH receptors have been detected in the human ovary, but their physiological importance is still unclear (). In particular, GnRH receptors as well as GnRH types I and II have been localized in the granulosa Fludarabine Phosphate receptor of pre-ovulatory follicles, but not of follicles fro

• So far GnRH receptors have been detected in the

  2022-09-05

  

  So far, GnRH receptors have been detected in the human ovary, but their physiological importance is still unclear (). In particular, GnRH receptors as well as GnRH types I and II have been localized in the granulosa Fludarabine Phosphate receptor of pre-ovulatory follicles, but not of follicles fro

• br Author s contributions br Conflict of interest br Acknowl

  2022-09-03

  

  Author's contributions Conflict of interest Acknowledgements This work was supported in part by a grant from Department of Biotechnology (DBT), Government of India (Sanction Order No.: BT/563/NE/U-Excel/2016). MC, PDG and SKM acknowledge the Ministry of Human Resource and Development (MHRD)

• Herein we report the discovery of

  2022-09-03

  

  Herein, we report the discovery of AM-3189 (). AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. As we reported previously, activity on the GPR40 receptor varies significantly with substitution at the β-carbon relative to

• br Experimental br Acknowledgments This

  2022-09-03

  

  Experimental Acknowledgments This project was generously supported by Grünenthal GmbH and IECB. We also thank the staff members of the technical platform of IECB and Grünenthal GmbH for their availability and their skills. Introduction Glucocorticoids (GCs) are essential steroid hormones t

• Multiple mechanisms have been suggested by which

  2022-09-03

  

  Multiple mechanisms have been suggested by which glucagon can increase energy expenditure although none have been conclusively proven to be responsible. Both enhanced gluconeogenesis and enhanced protein turnover secondary to hyperglucagonaemia have been suggested as the reason for the increased met

• Ghrelin readily crosses the blood brain barrier Banks

  2022-09-03

  

  Ghrelin readily crosses the blood (-)-Huperzine A barrier (Banks et al., 2002, Banks et al., 2008), and recent studies have identified central nervous system sites of action for ghrelin-mediated appetite and hyperphagia (Alvarez-Crespo et al., 2012, King et al., 2011, Schele et al., 2016, Skibicka

• Given the estimated number of

  2022-09-03

  

  Given the estimated number of 150–300 NSVDC channels in a red cell [7] and a single channel conductance of 30 pS at physiological salt concentrations [6], the maximum conductance observed in intact red dna ligase indicate either a very low open state probability, in the order of 10−3 or a far lower

• Galanin was shown to play an important role in pain

  2022-09-03

  

  Galanin was shown to play an important role in pain and pain processing [14] and the involvement of neuropeptides in the development of migraine is well established [[24], [25], [26]], however, so far it has not been examined whether systemic galanin levels correlate with migraine. Therefore, we use

• The effect of GC on Fgf was not

  2022-09-03

  

  The effect of GC on Fgf21 was not directly dependent on ileal Fgf15 because basal Fgf21 ha 47 was similar in Fgf15+/+ and Fgf15−/− mice. Moreover, GC treatment induced similar Fgf21 up-regulation in both strains. Fxr activation has been reported to increase Fgf21 expression and secretion [28]. In mi

15558 records 378/1038 page Previous Next First page 上5页 376377378379380 下5页 Last page