• Introduction Histamine Imidazolyl ethylamine is an important

  2022-02-11

  

  Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric daunorubicin secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine exe

• br Recently MST emerged as

  2022-02-11

  

  Recently, MST1 emerged as a critical regulator of leukocyte function and autoimmunity in humans. Five independent groups reported on autosomal recessive nonsense mutations in the gene STK4 (which encodes for MST1) in human patients with a novel primary immunodeficiency disease (PID), now called ST

• Substrate affinity and specificity can be enhanced by dockin

  2022-02-11

  

  Substrate affinity and specificity can be enhanced by docking interactions, in which regions distal to the site of sh4 bind to grooves, pockets, or surfaces outside of the kinase catalytic cleft 1, 2, 5, 6. Like catalytic site interactions, docking interactions can involve recognition of short line

• SIS3 Recent work by Que et al with

  2022-02-11

  

  Recent work by Que et al with mouse models implicates GSNOR in the cause of asthma. GSNOR is expressed in multiple cell types in the lung, including airway epithelial cells and infiltrating leukocytes. After exposure to ovalbumin, GSNOR activity increased in airway lining fluid, perhaps reflecting i

• Materials and Methods br Results br Discussion Activation

  2022-02-11

  

  Materials and Methods Results Discussion Activation of TLRs by damage-associated patterns is a well-recognized trigger for inflammation. TLR ligation results in a large increase in glycolytic metabolism in macrophages and other immune cells,12, 27 and we hypothesized that the glycolytic metab

• Nemadectin br Redox regulation in the brain Reactive oxygen

  2022-02-11

  

  Redox regulation in the brain Reactive oxygen species are generated in Nemadectin by the mitochondrial respiratory chain, which occurs on the inner mitochondrial membrane (Murphy, 2009, Jensen, 1966, Dickinson and Chang, 2011). Interestingly, although most cancer cells are thought to primarily re

• br STAR Methods br Acknowledgments We

  2022-02-11

  

  STAR★Methods Acknowledgments We would like to thank Dr. Xiping Cheng for help with the immunohistochemistry staining, Qi Su for help with gene expression analysis, and Dr. Chaoying Liang at the UTSW Genomics Microarray Core facility for assistance on RNA-seq. W.-H.L. was supported by grant awa

• Cellular inhibition is caused by the hyperpolarization of th

  2022-02-10

  

  Cellular inhibition is caused by the hyperpolarization of the cell and is mediated by both synaptic and extrasynaptic GABAARs. Synaptic GABAARs are sensitive to high concentrations of GABA released at the synapse and mediate phasic inhibition. In contrast, extrasynaptic GABAARs mediate tonic inhibit

• FDP is considered as key intermediate in the isoprenoid bios

  2022-02-10

  

  FDP is considered as key intermediate in the isoprenoid biosynthetic pathway, since it is the common precursor of polyisoprene units and farnesylated proteins (Cao et al., 2012). In order to understand the role of FDP gene in rubber-producing plants it is of critical importance to apexbt calculator

• Our results demonstrated that most of the HUA rings incubate

  2022-02-10

  

  Our results demonstrated that most of the HUA rings incubated with 100 μM TBT do not have the capacity to contract in the presence of 5-HT or exhibit very low contractions in comparison to the control. Only 23.3% of the HUA rings were able to contract. These results seem to indicate that there may b

• Another level of complexity within

  2022-02-10

  

  Another level of complexity within the TGF-ß/SMAD and Hippo/YAP/TAZ pathway crosstalks was recently uncovered. TGF-ß induces robust TAZ, but not YAP, protein expression in both mesenchymal and epithelial Indirubin through a SMAD3-independent, p38/MAPK-dependent mechanism that triggers myocardin-rela

• The experiments reported herein were designed to test whethe

  2022-02-10

  

  The experiments reported herein were designed to test whether co-expression of MRP and GSTP1-1 offers a level of protection from certain cytotoxic drugs not achieved by the expression of either protein alone. This was accomplished by stable transfection with expression vectors into MCF7/WT cells, w

• Introduction Multiple sclerosis MS a neurological

  2022-02-10

  

  Introduction Multiple sclerosis (MS), a neurological autoimmune disease, is driven by CD4+ cAMPS-Rp, triethylammonium salt receptor of the T helper (TH) cells [1]. There is no curative treatment for MS and the present treatments typically focus on immunomodulation for slowing the progression of th

• Historically pharmacological investigations have been carrie

  2022-02-10

  

  Historically, pharmacological investigations have been carried out by first identifying a biological response to a ligand, and then subsequently using that ligand to identify the receptor(s) responsible for the response (Wilson et al., 1998). However, this approach needed revision with the discovery

• br Conclusions Beta cell specific expression in human islets

  2022-02-10

  

  Conclusions Beta cell-specific expression in human islets of DGCR2, GBF1, GPR44 and SerpinB10 has not previously been described, although the proteins have partly been characterized in other contexts not related to beta 2076 or diabetes. DGCR2, GPR44 and SerpinB10 were negative in all other cell

15588 records 488/1040 page Previous Next First page 上5页 486487488489490 下5页 Last page