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To address this we developed approaches
2021-10-19
To address this, we developed approaches to image at high spatial and temporal resolution live WPB fusions as well as the release of VWF and other WPB cargo by spinning disk microscopy and combined laser ablation and total internal reflection fluorescence (TIRF) microscopy. Our live cell imaging rev
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CTGF is an established YAP
2021-10-19
CTGF is an established YAP/TAZ target gene which plays a central role in tissue remodeling. Downregulation of CTGF mediates collagen loss in chronologically-aged human skin whereas persistent activation of CTGF can result in excessive deposition of collagen and fibrotic disorders [63]. The authors f
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br Methods br Results br Discussion TA TMA
2021-10-19
Methods Results Discussion TA-TMA is a severe complication for patients after HSCT. The pathogenesis of TA-TMA is unclear. Complement activation and endothelial cell injury may be involved in the pathogenesis of TA-TMA. Our previous investigations had demonstrated that plasma levels of C5b-
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In addition to the importance of heme as an enzymatic
2021-10-19
In addition to the importance of heme as an enzymatic cofactor, heme also acts as an important iron source. In order to access the iron within heme, S. aureus encodes heme degrading enzymes known as heme oxygenases (Skaar et al., 2004b; Wu et al., 2005). The two heme oxygenases encoded by S. aureus,
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br An approach for the key challenges
2021-10-19
An approach for the key challenges facing forensic science One of the key challenges for forensic science is to avoid being side-tracked by one of the louder narratives in the media that the big problem forensic science faces is ‘junk science’ and ‘rogue scientists’. These are clearly important i
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Preadipocytes are capable of differentiating into lipid lade
2021-10-19
Preadipocytes are capable of differentiating into lipid-laden mature adipocytes. Lipid droplets are a prominent morphological feature of mature adipocytes, which is accumulated and maintained during adipocytes differentiation [26]. In this study, rHhip treatment increased lipid accumulation, as well
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The second approach to optimizing microsomal stability in th
2021-10-19
The second approach to optimizing microsomal stability in this series involved the strategic positioning of steric bulk along the tether as a means of encumbering the access of oxidative enzymes to the methylene bridge. This approach has been employed in other P2-P4 macrocyclic inhibitors of NS3/4A
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To identify structurally novel autophagy
2021-10-19
To identify structurally novel autophagy inhibitors, a medium throughput screen of our in-house library of approximately 160,000 compounds was performed. In the screening assay, MCF7 Tenofovir Disoproxil Fumarate stably transfected with eGFP-tagged light chain 3 (LC3), were employed, which can be d
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Spatial localization of zGC and zGCAP transcripts by
2021-10-19
Spatial localization of zGC and zGCAP transcripts by in situ hybridization was detected in the ONL. No transcripts were detected in the outermost periphery of the photoreceptor cell layer adjacent to the marginal zone. This region is described as the area of cone genesis and maturation [29], which f
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Signaling pathways that control the redox stress response in
2021-10-19
Signaling pathways that control the redox stress response in P. brasiliensis are poorly known, but in other dimorphic fungi, the involvement of MAPK is an important factor in this process [[13], [14], [15]]. For example, when alveolar macrophages are challenged with Aspergillus or Cryptococcus conid
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br Conclusion GST expression was detected in
2021-10-19
Conclusion GST expression was detected in the Hemicornea construct and the commonly used animal cornea models at both the protein and functional levels. The results are summarized in Table 1. However, the construct exhibited lower levels of activity of GST, a marker of phase II enzymatic activity
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The facts mentioned above indicate that
2021-10-19
The facts mentioned above indicate that glycine function in brain is tightly regulated or pathologically altered mostly by glycine transporters. Modification of cytosolic regions of transporters, which interconnect them with intracellular regulatory pathways, could be one of the ways to provoke brai
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br Acknowledgements This work was
2021-10-19
Acknowledgements This work was supported by the Science and Technology Department of Hubei Province (No.2016CFB368) and the National Natural Science Foundation of China (No. 81201053). Introduction L-Glutamate (glutamate) is the most important excitatory neurotransmitter of the central nervou
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Animal studies have shown that various antidepressant treatm
2021-10-19
Animal studies have shown that various antidepressant treatment are capable of upregulating GR protein and mRNA in key PF-562271 regions including the hippocampus and decreasing basal and/or stress-induced glucocorticoid secretion [37]. Changes in the level or function of GR regulate the negative f
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The receptor binding assay used
2021-10-18
The receptor binding assay used in our previous study demonstrated that propofol competitively binds to FPR1, thus blocking the downstream signal transduction of FPR1 and inhibiting neutrophil immune activities [8]. In this study, we assessed the pharmacological action of fMMYALF in the presence of
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