• SIRT is a representative member of Sirtuins which is

  2020-09-01

  

  SIRT1 is a representative member of Sirtuins, which is a family of highly conserved NAD+-dependent class III histone deacetylases. SIRT1 deacetylates plentiful nonhistone protein substrates [Atgs, Foxo1, Foxo3, PGC-1α, NF-kB, E2F1 and p53] (Conrad et al., 2016; Gu et al., 2016; Tu et al., 2018) to p

• br Acknowledgements The authors are supported by National In

  2020-09-01

  

  Acknowledgements The authors are supported by National Institutes of Health grants (CA162804, CA92584, and CA13499 to DJC and CA166677 to BPPC) and Cancer Prevention and Research Institute of Texas (RP110465 to DJC). The cellular response to DNA double-strand break (DSB) formation is an essent

• br Materials and methods br Results br

  2020-08-31

  

  Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic Lu AA 47070 induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter status ep

• br Application of D receptor PET in psychiatric disorders

  2020-08-31

  

  Application of D1-receptor PET in psychiatric disorders Discussion Compared to other markers of the DA system, only a limited number of studies have investigated D1-R in psychiatric disorders. In schizophrenia, which is the most studied condition with a total of 83 identified unique patients,

• br Conclusions In this paper we describe

  2020-08-31

  

  Conclusions In this paper we describe the recombinant expression and characterization of ParI, a C5-DNA-MTase from P. arcticus 273–4. To our knowledge, this is the first characterization of an orphan C5-DNA-MTase from a psychrophilic bacterium. The C5-DNA-MTase could not be expressed in regular E

• br Conclusions This report describes

  2020-08-31

  

  Conclusions This report describes the discovery of a new class of host-directed antiviral agents characterized by a 1-aryl-4,6-diamino-1,2-dihydrotriazine scaffold, responsible for a host (human) DHFR inhibition mechanism. Host-targeting antivirals represent an alternative and emerging strategy t

• Studies of Jelski and Szmitkowski show that differences of a

  2020-08-31

  

  Studies of Jelski and Szmitkowski show that differences of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity between Fosmidomycin sodium salt of many cancers and healthy tissue may be one of the factors intensifying carcinogenesis [7]. Moreover, changes of ADH and ALDH activity

• Introduction The carnitine choline acyltransferase

  2020-08-31

  

  Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) Tirapazamine sale and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists

• l-name br Concluding remarks and prospective

  2020-08-31

  

  Concluding remarks and prospective Cardiac proteinopathy, a more common disease condition and more frequent cause of cardiomyocyte decay than previously thought, is largely neglected and no effective therapy exists yet. Protein quality control and protein degradation via autophagy or the ubiquiti

• The estrogen receptor ER dependent signaling pathway plays a

  2020-08-31

  

  The estrogen receptor(ER)-dependent signaling pathway plays an important role in bone metabolism by restoring the balance between osteoblastic bone formation and osteoclastic bone resorption [21]. ER has two major isoforms, ERalpha (ER-α) and ERbeta (ER-β), which mediate the effect of estrogen and o

• The most significant finding was

  2020-08-31

  

  The most significant finding was the inhibition of EROD and BFCOD activity by CLO. Inhibition of EROD and BFCOD were reversible, as pre-incubation did not enhance CLO inhibitory potency, and no reductions in IC50 values were observed. We further characterized the kinetic pattern of inhibition using

• The BMP family comprises significant growth

  2020-08-28

  

  The BMP family comprises significant growth factors for the regeneration of bone and cartilage. Among these, BMP- has been known as an early marker during the proliferation of osteoblast cells, and one of the most potent stimulators of osteoblastic cells differentiation [40]. Studies with COX-2 knoc

• Recently we have demonstrated that

  2020-08-28

  

  Recently we have demonstrated that the synthesis of cysteinyl-LTs from LTA4 by human umbilical vein endothelial cells (HUVECs) is directly associated with the activation of the CysLT2 receptor (CysLT2R) in a typical autocrine fashion, and that solely the CysLT2R is responsible for the increase in in

• N,N-Dimethylsphingosine CXCL mediated cell migration is faci

  2020-08-28

  

  CXCL16 mediated cell migration is facilitated by the interaction of soluble CXCL16 with CXCR6, expressed predominantly on the cell surface of CD4+ Th1 cells, cancer infiltrating lymphocytes and platelets (Borst et al., 2012, Kim et al., 2001, Liao et al., 1997, Wilbanks et al., 2001). CXCR6 is invol

• We then analyzed Ki proliferation

  2020-08-27

  

  We then analyzed Ki-67 proliferation index as a categorical variable by using 15%, essentially the median Ki-67 value in the entire study group (see above), to delineate low and high proliferation subgroups. By Fisher\'s exact test, both the type 1 versus non-type 1 EWS-FLI1 comparison (P = 0.047; T

15955 records 810/1064 page Previous Next First page 上5页 806807808809810 下5页 Last page